A study shows that asymptomatic women who have been treated for early-stage breast cancer often undergo advanced imaging and other tests that provide little if any medical benefit, could have harmful effects and may increase their financial burden.
The research findings imply that patients with genitourinary birth defects due to 22q11.2 changes in gene dosage should also be evaluated for other potential birth defects seen in patients with DiGeorge syndrome that would affect the patient's future health.
Researchers find through looking at genetic data sets of presumed cancer-free women who carry BRCA 1/2 variants, the co-occurrence of a rare COMT genetic variant in some women. This research outlines a strategy for looking at large genetic data sets for clues as to why a genetic carrier may never develop the associated diseases.
While the increasing accessibility of data from scientific studies creates many benefits -- and represents a process that should be broadly embraced -- in the context of conserving endangered species it can actually be problematic, experts say.
A new global assessment reveals that increases in leaf abundance are causing boreal areas to warm and arid regions to cool. The results suggest that recent changes in global vegetation have had impacts on local climates that should be considered in the design of local mitigation and adaptation plans.
Infections, chronic high blood pressure and bleeding or clotting disorders increase the risk of pregnancy-related stroke in women with preeclampsia. Although pregnancy-related stroke is rare, women with preeclampsia are at higher risk of stroke during pregnancy and postpartum.
Researchers have announced that six boxes of fruit flies (Drosophila melanogaster) will travel to the International Space Station (ISS) to study the impact of weightlessness on the heart. The fruit flies are scheduled to launch on June 1, 2017, from NASA’s Kennedy Space Center and will travel to the ISS via a SpaceX Dragon spacecraft.
In a small, randomized Phase I/II clinical trial (SAT1), researchers say a 100-year-old drug called suramin, originally developed to treat African sleeping sickness, was safely administered to children with autism spectrum disorder (ASD), who subsequently displayed measurable, but transient, improvement in core symptoms of autism.
Melanoma is a particularly difficult cancer to treat once it has metastasized, spreading throughout the body. Researchers are using chemistry to find the deadly, elusive malignant cells within a melanoma tumor that hold the potential to spread. Once found, the stemlike metastatic cells can be cultured and screened for their response to a variety of anti-cancer drugs, providing the patient with an individualized treatment plan based on their own cells.
Within the plant microbiota, mutualistic fungal and bacterial symbionts are striking examples of microorganisms playing crucial roles in nutrient acquisition. They have coevolved with their hosts since initial plant adaptation to land. Despite the evolutionary distances that separate mycorrhizal and nitrogen-fixing symbioses, these associations share a number of highly conserved features, including specific plant symbiotic signaling pathways, root colonization strategies that circumvent plant immune responses, functional host-microbe interface formation, and the central role of phytohormones in symbiosis-associated root developmental pathways. We highlight recent and emerging areas of investigation relating to these evolutionarily conserved mechanisms, with an emphasis on the more ancestral mycorrhizal associations, and consider to what extent this knowledge can contribute to an understanding of plant-microbiota associations as a whole.