Wednesday, 29 March 2017
News with tag Breast cancer  RSS
More Women With Breast Cancer Opt to Remove Healthy Breast

Added: 29.03.2017 16:22 | 0 views | 0 comments

One in three breast cancer patients under 45 in 2012 removed the healthy breast along with the breast affected by cancer, a new study found.


Mammography vs. thermography: Comparing the benefits

Added: 29.03.2017 14:00 | 0 views | 0 comments

Mammography and thermography are two methods of detecting abnormalities that may indicate breast cancer. Learn this article.


Novel approach can reveal personalized breast cancer treatments

Added: 28.03.2017 15:24 | 1 views | 0 comments

Researchers have developed a new way to approach breast cancer treatment. First, they search for the proteins that drive tumor growth, and then test in the lab drugs that potentially neutralize these specific biological drivers.

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Metastatic breast cancer: Symptoms, treatment, and outlook

Added: 25.03.2017 7:00 | 1 views | 0 comments

Metastatic breast cancer can occur if the initial cancer treatment isn't successful and the cancer spreads to other parts of the body. Learn about it here.


Dogs can detect breast cancer by smelling a bandage

Added: 24.03.2017 22:26 | 1 views | 0 comments

With just six months of training, a pair of German Shepherds became 100-percent accurate in their new role as breast cancer spotters, researchers with project Kdog, in France, said.


[Report] A conserved NAD+ binding pocket that regulates protein-protein interactions during aging

Added: 23.03.2017 18:23 | 2 views | 0 comments

DNA repair is essential for life, yet its efficiency declines with age for reasons that are unclear. Numerous proteins possess Nudix homology domains (NHDs) that have no known function. We show that NHDs are NAD+ (oxidized form of nicotinamide adenine dinucleotide) binding domains that regulate protein-protein interactions. The binding of NAD+ to the NHD domain of DBC1 (deleted in breast cancer 1) prevents it from inhibiting PARP1 [poly(adenosine diphosphate–ribose) polymerase], a critical DNA repair protein. As mice age and NAD+ concentrations decline, DBC1 is increasingly bound to PARP1, causing DNA damage to accumulate, a process rapidly reversed by restoring the abundance of NAD+. Thus, NAD+ directly regulates protein-protein interactions, the modulation of which may protect against cancer, radiation, and aging. Authors: Jun Li, Michael S. Bonkowski, Sébastien Moniot, Dapeng Zhang, Basil P. Hubbard, Alvin J. Y. Ling, Luis A. Rajman, Bo Qin, Zhenkun Lou, Vera Gorbunova, L. Aravind, Clemens Steegborn, David A. Sinclair


[Report] PI3K pathway regulates ER-dependent transcription in breast cancer through the epigenetic regulator KMT2D

Added: 23.03.2017 18:23 | 2 views | 0 comments

Activating mutations in PIK3CA, the gene encoding phosphoinositide-(3)-kinase α (PI3Kα), are frequently found in estrogen receptor (ER)–positive breast cancer. PI3Kα inhibitors, now in late-stage clinical development, elicit a robust compensatory increase in ER-dependent transcription that limits therapeutic efficacy. We investigated the chromatin-based mechanisms leading to the activation of ER upon PI3Kα inhibition. We found that PI3Kα inhibition mediates an open chromatin state at the ER target loci in breast cancer models and clinical samples. KMT2D, a histone H3 lysine 4 methyltransferase, is required for FOXA1, PBX1, and ER recruitment and activation. AKT binds and phosphorylates KMT2D, attenuating methyltransferase activity and ER function, whereas PI3Kα inhibition enhances KMT2D activity. These findings uncover a mechanism that controls the activation of ER by the posttranslational modification of epigenetic regulators, providing a rationale for epigenetic therapy in ER-positive breast cancer. Authors: Eneda Toska, Hatice U. Osmanbeyoglu, Pau Castel, Carmen Chan, Ronald C. Hendrickson, Moshe Elkabets, Maura N. Dickler, Maurizio Scaltriti, Christina S. Leslie, Scott A. Armstrong, José Baselga


FDA Links 9 Deaths to a Rare Cancer Associated with Breast Implants

Added: 23.03.2017 12:25 | 0 views | 0 comments

A rare type of cancer believed to be caused by breast implants has now been linked to nine deaths. The Federal Drug Administration released an update on Tuesday to a 2011 report about a rare form of cancer, not linked to breast cancer, called anaplastic large cell lymphoma (ALCL), which included its findings over the last six years. The agency’s original report stated that this rare form of cancer is believed to be caused by breast implants and is not ...

PHD2 targeting overcomes breast cancer cell death upon glucose starvation

Added: 23.03.2017 7:00 | 2 views | 0 comments

B55α is one of the regulatory subunits of the PP2A phosphatase. This phosphatases has been associated to the control of many biological functions but the multiplicity of complexes that can be...


Breast cancer: Study identifies a molecular mechanism of drug resistance in ER+ tumors

Added: 21.03.2017 14:00 | 1 views | 0 comments

Study suggests that a mechanism of drug resistance in ER+ breast cancers could be changes to the estrogen receptor caused by two immune system molecules.


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